Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor

被引：4

作者：

Endo, M ^{[1
]}

Usuki, K ^{[1
]}

Kitazume, K ^{[1
]}

Iwabe, K ^{[1
]}

Okuyama, Y ^{[1
]}

Urabe, A ^{[1
]}

机构：

[1] KANTO TEISHIN HOSP,DIV HEMATOL,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

ANNALS OF HEMATOLOGY | 1995年 / 71卷 / 06期

关键词：

Hodgkin's; IL-5; GM-CSF; eosinophilia;

D O I：

10.1007/s002770050125

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a patient with eosinophilia accompanied by Hodgkin's disease who showed remarkable increase in granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma but no increase in interleukin-5 (IL-5). The plasma GM-CSF level normalized as eosinophilia and lymphadenopathy disappeared after chemotherapy. Immunohistochemical study with immunoperoxidase staining technique showed a positive stain in lymph node cells by monoclonal anti-GM-CSF antibody. Eosinophilia is often accompanied by Hodgkin's disease, and several cases have been reported to show high levels of plasma IL-5. To our knowledge, this is the first report to show a high level of plasma GMCSF in Hodgkin's disease with eosinophilia.

引用

页码：313 / 314

页数：2

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