Hypereosinophilic syndrome in Hodgkin's disease with increased granulocyte-macrophage colony-stimulating factor

被引：4
|
作者：
Endo, M [1 ]
Usuki, K [1 ]
Kitazume, K [1 ]
Iwabe, K [1 ]
Okuyama, Y [1 ]
Urabe, A [1 ]
机构：
[1] KANTO TEISHIN HOSP,DIV HEMATOL,SHINAGAWA KU,TOKYO 141,JAPAN
来源：
ANNALS OF HEMATOLOGY | 1995年 / 71卷 / 06期
关键词：
Hodgkin's; IL-5; GM-CSF; eosinophilia;
D O I：
10.1007/s002770050125
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a patient with eosinophilia accompanied by Hodgkin's disease who showed remarkable increase in granulocyte-macrophage colony-stimulating factor (GM-CSF) in plasma but no increase in interleukin-5 (IL-5). The plasma GM-CSF level normalized as eosinophilia and lymphadenopathy disappeared after chemotherapy. Immunohistochemical study with immunoperoxidase staining technique showed a positive stain in lymph node cells by monoclonal anti-GM-CSF antibody. Eosinophilia is often accompanied by Hodgkin's disease, and several cases have been reported to show high levels of plasma IL-5. To our knowledge, this is the first report to show a high level of plasma GMCSF in Hodgkin's disease with eosinophilia.
引用
收藏
页码：313 / 314
页数：2
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