INFECTION OF HUMAN ENDOTHELIAL-CELLS BY RICKETTSIA-RICKETTSII CAUSES A SIGNIFICANT REDUCTION IN THE LEVELS OF KEY ENZYMES INVOLVED IN PROTECTION AGAINST OXIDATIVE INJURY

被引：19

作者：

DEVAMANOHARAN, PS ^{[1
]}

SANTUCCI, LA ^{[1
]}

HONG, JE ^{[1
]}

TIAN, XJ ^{[1
]}

SILVERMAN, DJ ^{[1
]}

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 06期

关键词：

D O I：

10.1128/IAI.62.6.2619-2621.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activities of glucose-6-phosphate dehydrogenase, catalase, and glutathione peroxidase were significantly decreased in human endothelial cells infected with the obligate intracellular bacterium Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever. This observation lends additional support to our hypothesis implicating oxidative damage in endothelial cell injury caused by this microorganism.

引用

页码：2619 / 2621

页数：3

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