ELASTASE, EXOTOXIN-A AND ALKALINE PROTEASE PRODUCTION DURING PULMONARY EXACERBATIONS IN CYSTIC-FIBROSIS PATIENTS CHRONICALLY INFECTED BY PSEUDOMONAS-AERUGINOSA

被引：0

作者：

JAFFARBANDJEE, MC ^{[1
]}

CARRERE, J ^{[1
]}

BALLY, M ^{[1
]}

CHAZALETTE, JP ^{[1
]}

GALABERT, C ^{[1
]}

机构：

[1] HOP R SABRAN GIENS, CNRS, F-83406 HYERES, FRANCE

来源：

PATHOLOGIE BIOLOGIE | 1994年 / 42卷 / 05期

关键词：

PSEUDOMONAS-AERUGINOSA; CYSTIC FIBROSIS; VIRULENCE FACTORS; EXACERBATION;

D O I：

暂无

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The authors have studied the production of exoproteins by Pseudomonas aeruginosa in the sputa of 18 patients suffering from cystic fibrosis, during 29 bronchopulmonary exacerbations and also after the recovery of a stable state. Significant levels of exoproteins were detected but with a large heterogenity of intra and inter individual variations. A significant decrease in the production of the three exoproteins was found after twelve days of antibiotherapy, without any correlation between exoprotein levels and colony forming units in the sputa. During the intercrisis phase, exoproteins levels were practically undetectable. These facts and the good correlation between clinical symptoms support the hypothesis of a renewal of virulence of Pseudomonas aeruginosa during these periods of bronchopulmonary exacerbation in cystic fibrosis.

引用

页码：505 / 509

页数：5

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