BLOOD-PRESSURE VARIABILITY AND REFLEX CONTROL IN THE ELDERLY

被引：15

作者：

MANCIA, G

DIRIENZO, M

GRASSI, G

PARATI, G

机构：

[1] University of Milan, St. Gerardo Hospital, Monza, Milano

[2] LARC, Bioengineering Center, Pro Juventute Foundation, Milano

[3] Centro Auxologico Italiano, St. Luca Hospital, Milano

[4] Cattedra di Medicina Interna, Università di Milano, Ospedale S. Gerardo, Monza, 20052

来源：

AGING-CLINICAL AND EXPERIMENTAL RESEARCH | 1995年 / 7卷 / 01期

关键词：

AGING; ARTERIAL BARORECEPTORS; BLOOD PRESSURE VARIABILITY; CARDIOPULMONARY RECEPTORS; SYMPATHETIC ACTIVITY;

D O I：

10.1007/BF03324282

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Several lines of experimental and clinical evidence collected over the past ten years suggest that the aging process is characterized not only by profound structural cardiovascular alterations, but also by marked functional changes in the reflex mechanisms involved in the homeostatic control of the circulation. This paper will examine how aging affects baroreceptor control of the heart and sympathetic nerve traffic, providing evidence that while the for mer is markedly impaired in the elderly, the latter is virtually preserved. It will also discuss the age-related alterations in cardiopulmonary receptor function that, under physiological conditions, tonically inhibit sympathetic vasoconstriction tone and renin release from the kidney. Finally, evidence will be provided showing that short- and long-term blood pres sure variabilities (and the different components of blood pressure variability) over 24 hours undergo major changes in the elderly. All these alterations in neural cardiovascular control mechanisms have clearcut clinical implications representing a potential marker of the increased cardiovascular risk which characterizes elderly people.

引用

页码：3 / 9

页数：7

共 49 条

[1]

Lund-Johansen P., Hemodynamic and cardiac changes with aging, High Blood Pressure, 3, pp. 111-118, (1994)

[2]

Ferrari A.U., Grassi G., Mancia G., Alterations in reflex control of the circulation associated with aging, Handbook of Hypertension, Vol. 12. Hypertension in the Elderly, pp. 39-50, (1989)

[3]

Lakatta E.G., Cardiovascular reserve capacity in healthy older humans, Aging Clin. Exp. Res., 6, pp. 213-223, (1994)

[4]

Giannattasio C., Ferrari A.U., Mancia G., Alterations in neural cardiovascular control mechanisms with aging, J. Hypertens., 12, 6, (1994)

[5]

Mancia G., Mark A.L., Arterial baroreflexes in humans, Handbook of Physiology, the Cardiovascular System: Peripheral Circulation and Organ Blood Flow, pp. 755-794, (1983)

[6]

Korner P.I., West M.J., Shaw J., Uther J.B., Steady-state properties of the baroreceptors-heart rate reflex in essential hypertension in man, Clin. Exp. Pharmacol. Physiol., 1, pp. 65-76, (1974)

[7]

Gribbin B., Pickering T.G., Sleight P., Peto R., Effect of age ang high blood pressure on baroreflex sensitivity in man, Circ. Res., 29, pp. 424-431, (1971)

[8]

Duke P.C., Wade J.G., Hickey R.F., Larson C.P., Effects of age on baroreceptor function in man, Can. Anesth. Soc., 23, pp. 111-124, (1976)

[9]

Mancia G., Ferrari A., Gregorini L., Valentini R., Ludbrook J., Zanchetti A., Circulatory reflexes from carotid and extracarotid baroreceptor areas in man, Circ. Res., 41, pp. 309-315, (1977)

[10]

Bertinieri G., Di Rienzo M., Cavallazzi A., Ferrari A.U., Pedotti A., Mancia G., A new approach to analysis of the arterial baroreflex, Am. J. Physiol., 254, (1988)

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