HUMAN N-METHYL-D-ASPARTATE RECEPTOR MODULATORY SUBUNIT HNR2A - CLONING AND SEQUENCING OF THE CDNA AND PRIMARY STRUCTURE OF THE PROTEIN

被引：22
作者：
FOLDES, RL
ADAMS, SL
FANTASKE, RP
KAMBOJ, RK
机构：
[1] Allelix Biopharmaceuticals Inc., Mississauga, Ont. L4V 1V7
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1994年 / 1223卷 / 01期
关键词：
N-METHYL-D-ASPARTATE RECEPTOR; NMDA RECEPTOR; NR2A; CDNA SEQUENCE; AMINO ACID SEQUENCE; (HUMAN);
D O I：
10.1016/0167-4889(94)90086-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several cDNA clones encoding the human N-methyl-D-aspartate receptor modulatory subunit hNR2A, were isolated from human hippocampus and fetal brain libraries. DNA sequence analysis revealed overlapping clones permitting the reconstruction of full-length hNR2A cDNA. The hNR2A cDNA demonstrated an 88-89% nucleotide(nt) identity with the corresponding rodent cDNAs. The nt sequence of hNR2A would encode a 1464-aa protein that has a 95.2% identity with the rodent NR2A subunits.
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收藏
页码：155 / 159
页数：5
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