IMMUNOHISTOCHEMICAL CHARACTERIZATION OF AN AMPHICRINE MUCINOUS ISLET-CELL CARCINOMA OF THE PANCREAS - CASE-REPORT

被引：19
作者：
LAINE, VJO
EKFORS, TO
GULLICHSEN, R
NEVALAINEN, TJ
机构：
[1] UNIV TURKU,DEPT PATHOL,SF-20520 TURKU 52,FINLAND
[2] UNIV TURKU,CENT HOSP,DEPT SURG,SF-20520 TURKU 52,FINLAND
来源：
APMIS | 1992年 / 100卷 / 04期
关键词：
AMPHICRINE CARCINOMA; PANCREAS; DNA FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY;
D O I：
10.1111/j.1699-0463.1992.tb00880.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immunohistochemical characteristics of a mucinous islet-cell carcinoma of the pancreas are described. The tumour presented with jaundice in a 59-year-old male. It consisted of polygonal atypical cells forming a reticular pattern, and invaded the common bile duct. In DNA flow cytometry, the tumour cells showed a clear-cut aneuploid peak. Intercellular mucin was abundant. A panel of antisera and monoclonal markers was applied in the immunohistochemical analysis. In addition to general epithelial and endocrine markers, the tumour cells showed a focal positive immunoreaction with anti-glucagon, anti-insulin, anti-vasoactive intestinal polypeptide, anti-pancreatic secretory trypsin inhibitor and anti-phospholipase A2 antigen. At the ultrastructural level, mucous and neuroendocrine granules were demonstrated in the same tumour cells.
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页码：335 / 340
页数：6
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