VANADIUM(IV) COMPLEXES OF AN ACTIVE-SITE PEPTIDE OF A PROTEIN, TYROSINE PHOSPHATASE

被引：47

作者：

CORNMAN, CR

ZOVINKA, EP

MEIXNER, MH

机构：

[1] Department of Chemistry, North Carolina State University, Raleigh

[2] Department of Chemistry, Mathematics, Physical Science, Saint Francis College, Loretto

来源：

INORGANIC CHEMISTRY | 1995年 / 34卷 / 21期

关键词：

D O I：

10.1021/ic00125a002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Vanadium(IV) inhibition of protein tyrosine phosphatases may be responsible for the insulin mimetic effect of vanadium. Electron paramagnetic resonance spectral data for vanadyl complexes of VHCSAG-NH2 (an active-site peptide of PTP-1B) between pH 5 and 9, as well as the derivatives VFCSAG-NH2, VHMSAG-NH2, and VHCGAG-NH2 suggests that the histidine or cysteine side-chain heteroatoms coordinate to the vanadyl ion while the serine hydroxyl remains uncoordinated.

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页码：5099 / &

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