IS HYPUSINE ESSENTIAL FOR EUKARYOTIC CELL-PROLIFERATION

被引：148

作者：

PARK, MH

WOLFF, EC

FOLK, JE

机构：

[1] Enzyme Chemistry Section, Laboratory of Cellular Development and Oncology, National Institute of Dental Research, Bethesda, MD 20892, Building 30

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 12期

关键词：

D O I：

10.1016/0968-0004(93)90010-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hypusine [N(epsilon)-(4-amino-2-hydroxybutyl)-L-lysine] is a most remarkable amino acid, occurring in all eukaryotic cells, yet occupying only a single position in one protein, eukaryotic protein synthesis initiation factor 5A (eIF-5A). The unusual structure of hypusine, its derivation from the polyamine spermidine, and its increased formation in response to growth stimulation, as well as its limited occurrence in the highly conserved amino acid sequence of eIF-5A, have aroused keen interest in the biological significance of its existence and in its relationship to eIF-5A function.

引用

页码：475 / 479

页数：5

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