VINYL CHLORIDE-INDUCED DEPRESSION OF HEPATIC NON-PROTEIN SULFHYDRYL CONTENT AND EFFECTS ON BROMOSULFOPHTHALEIN (BSP) CLEARANCE IN RATS

被引：53

作者：

WATANABE, PG ^{[1
]}

HEFNER, RE ^{[1
]}

GEHRING, PJ ^{[1
]}

机构：

[1] DOW CHEM CO, TOXICOL RES INST, MIDLAND, MI 48640 USA

来源：

TOXICOLOGY | 1976年 / 6卷 / 01期

关键词：

D O I：

10.1016/0300-483X(76)90002-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rats were exposed to atmospheres of 2000, 1000, 250, 150, 50 and 10 ppm vinyl chloride [VC, a reported carcinogen] for 1-7 h to determine the effect of VC on the hepatic non-protein sulfhydryl content. Exposure to 2000, 1000, 250 and 150 ppm VC caused a progressive depression of the hepatic non-protein sulfhydryl content. Following exposure to 50 ppm VC for 7 h the depression was inconsistent, and no depression was observed after 10 ppm VC for 7 h. Exposure to 1000 ppm VC did not alter the serum clearance of bromosulphalein. [Occupational untoward effects in humans are discussed.].

引用

收藏

页码：1 / 8

页数：8

相关论文

共 25 条

[1] ESTIMATION AND IDENTIFICATION OF THIOLS IN RAT SPLEEN AFTER CYSTEINE OR GLUTATHIONE TREATMENT - RELEVANCE TO PROTECTION AGAINST NITROGEN MUSTARDS [J].

BALL, CR .

BIOCHEMICAL PHARMACOLOGY, 1966, 15 (07) :809-&

[2]

BLOCH K, 1947, J BIOL CHEM, V169, P765

[3] REDUCTION OF TOXICITY OF RADIOMIMETIC ALKYLATING AGENTS IN RATS BY THIOL PRETREATMENT PART .2. MECHANISM OF PROTECTION [J].

CALCUTT, G ;

ROSS, WCJ ;

CONNORS, TA ;

ELSON, LA .

BIOCHEMICAL PHARMACOLOGY, 1963, 12 (08) :833-&

[4]

CREECH JL, 1974, J OCCUP ENVIRON MED, V16, P150

[5]

DOUGLAS GW, 1956, J BIOL CHEM, V222, P581

[6] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .1. CORRELATION OF CHANGES IN COVALENT BINDING OF REACTIVITY METABOLITES WITH CHANGES IN INCIDENCE AND SEVERITY OF TOXICITY [J].

GILLETTE, JR .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (20) :2785-2794

[7] PERSPECTIVE ON ROLE OF CHEMICALLY REACTIVE METABOLITES OF FOREIGN COMPOUNDS IN TOXICITY .2. ALTERATIONS IN KINETICS OF COVALENT BINDING [J].

GILLETTE, JR .

BIOCHEMICAL PHARMACOLOGY, 1974, 23 (21) :2927-2938

[8] A STUDY OF COMPARATIVE PROTECTION AGAINST LETHALITY OF TRIETHYLENEMELAMINE, NITROGEN MUSTARD, AND I-IRRADIATION IN MICE [J].

GOLDENTHAL, EI ;

NAKARNI, MV ;

SMITH, PK .

RADIATION RESEARCH, 1959, 10 (05) :571-583

[9] DIFFERENTIAL TOXICITY OF MONOCHLOROACETATE, MONOFLUOROACETATE AND MONOIODOACETATE IN RATS [J].

HAYES, FD ;

SHORT, RD ;

GIBSON, JE .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1973, 26 (01) :93-102

[10] PRELIMINARY STUDIES OF FATE OF INHALED VINYL-CHLORIDE MONOMER IN RATS [J].

HEFNER, RE ;

WATANABE, PG ;

GEHRING, PJ .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1975, 246 (JAN31) :135-148