The role of fibrocytes in fibrotic diseases of the lungs and heart

被引：55

作者：

Keeley, Ellen C. ^{[1
]}

Mehrad, Borna ^{[2
]}

Strieter, Robert M. ^{[2
]}

机构：

[1] Univ Virginia, Dept Med, Div Cardiol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Med, Pulm & Crit Care Med, Lee St, Charlottesville, VA 22908 USA

来源：

FIBROGENESIS & TISSUE REPAIR | 2011年 / 4卷

关键词：

D O I：

10.1186/1755-1536-4-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fibrosis is the end result of a complex series of events that follow tissue injury and inflammation. Pathophysiologic fibrosis results in permanent scar formation, and can impair organ function. Fibrocytes are circulating, bone-marrow-derived progenitor cells that traffic from the bone marrow to the injured organ via the bloodstream, where they differentiate into fibroblasts and myofibroblasts, and play a pivotal role in both physiologic and aberrant fibrosis. In this review, we focus on the contribution of fibrocytes to fibrotic diseases of the lungs and the heart, including interstitial lung diseases, asthma, pulmonary hypertension, atherosclerosis and ischemic cardiomyopathy.

引用

页数：6

共 50 条

[1] Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites [J].

Abe, R ;

Donnelly, SC ;

Peng, T ;

Bucala, R ;

Metz, CN .

JOURNAL OF IMMUNOLOGY, 2001, 166 (12) :7556-7562

[2]

American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias, 2001, AM J RESP CRIT CARE, V165, P277, DOI [10.1164/ajrccm.165.2.ats01, DOI 10.1164/AJRCCM.165.2.ATS01]

[3] Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis [J].

Andersson-Sjoland, Annika ;

de Alba, Carolina Garcia ;

Nihlberg, Kristian ;

Becerril, Carina ;

Ramirez, Remedios ;

Pardo, Annie ;

Westergren-Thorsson, Gunilla ;

Selman, Moises .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (10) :2129-2140

[4] CD34+ fibrocytes in normal mitral valves and myxomatous mitral valve degeneration [J].

Barth, PJ ;

Köster, H ;

Moosdorf, R .

PATHOLOGY RESEARCH AND PRACTICE, 2005, 201 (04) :301-304

[5] CIRCULATING FIBROCYTES DEFINE A NEW LEUKOCYTE SUBPOPULATION THAT MEDIATES TISSUE-REPAIR [J].

BUCALA, R ;

SPIEGEL, LA ;

CHESNEY, J ;

HOGAN, M ;

CERAMI, A .

MOLECULAR MEDICINE, 1994, 1 (01) :71-81

[6] Induction of the CXC Chemokine Interferon-γ-Inducible Protein 10 Regulates the Reparative Response Following Myocardial Infarction [J].

Bujak, Marcin ;

Dobaczewski, Marcin ;

Gonzalez-Quesada, Carlos ;

Xia, Ying ;

Leucker, Thorsten ;

Zymek, Pawel ;

Veeranna, Vikas ;

Tager, Andrew M. ;

Luster, Andrew D. ;

Frangogiannis, Nikolaos G. .

CIRCULATION RESEARCH, 2009, 105 (10) :973-983

[7] The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ [J].

Chesney, J ;

Bacher, M ;

Bender, A ;

Bucala, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6307-6312

[8]

Chesney J, 1998, J IMMUNOL, V160, P419

[9] Human circulating fibrocytes have the capacity to differentiate osteoblasts and chondrocytes [J].

Choi, Young H. ;

Burdick, Marie D. ;

Strieter, Robert M. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (05) :662-671

[10] Bone Marrow-Derived Cells Contribute to Fibrosis in the Chronically Failing Heart [J].

Chu, Po-Yin ;

Mariani, Justin ;

Finch, Samara ;

McMullen, Julie R. ;

Sadoshima, Junichi ;

Marshall, Tanneale ;

Kaye, David M. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (04) :1735-1742

← 1 2 3 4 5 →