SELECTIVE BRAIN COOLING INCREASES CORTICAL CEREBRAL BLOOD-FLOW IN RATS

被引：65
作者：
KULUZ, JW [1 ]
PRADO, R [1 ]
CHANG, J [1 ]
GINSBERG, MD [1 ]
SCHLEIEN, CL [1 ]
BUSTO, R [1 ]
机构：
[1] UNIV MIAMI, SCH MED, CEREBRAL VASC DIS RES CTR, DEPT NEUROL, MIAMI, FL 33101 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 03期
关键词：
HYPOTHERMIA; CEREBRAL VASCULAR RESISTANCE; TEMPERATURE; LASER-DOPPLER FLOWMETRY;
D O I：
10.1152/ajpheart.1993.265.3.H824
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
To evaluate the effect of selective brain cooling on cortical cerebral blood flow, we reduced brain temperature in nitrous oxide anesthetized adult rats using a high speed fan while keeping rectal temperature at 37-38-degrees-C. During selective brain cooling, cortical cerebral blood flow, as measured by laser-Doppler flowmetry, increased to 215 +/- 26% (mean +/- SE) of baseline at a cortical brain temperature of 30.9 +/- 0.5-degrees-C and a rectal temperature of 37.5 +/- 0.1-degrees-C. During rewarming, as brain temperature increased, cortical cerebral blood flow decreased. The cerebral vasodilatory response to hypothermia may explain its protective effects during and after cerebral ischemia.
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收藏
页码：H824 / H827
页数：4
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