SIGNALING PATHWAYS INITIATED BY RECEPTOR PROTEIN-TYROSINE KINASES IN DROSOPHILA

被引：92
作者：
PERRIMON, N
机构：
[1] N Perrimon, Howard Hughes Medical Institute, Department of Genetics, Boston, MA 02115
来源：
CURRENT OPINION IN CELL BIOLOGY | 1994年 / 6卷 / 02期
关键词：
D O I：
10.1016/0955-0674(94)90145-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The isolation and characterization of Drosophila mutations in receptor protein tyrosine kinases (RPTKs) have allowed a detailed analysis of the cellular processes regulated by these proteins. Recent investigations have identified a number of putative ligands involved in the activation of the receptors, and have demonstrated that these RPTKs trigger an evolutionarily conserved biochemical pathway. In addition to molecules previously identified from vertebrate studies, i.e. Grb2, Sos, Ras-Gap, p21(ras) Raf, MEK and MAPK, genetic studies have suggested that two novel proteins, the protein tyrosine phosphatase (PTPase) Csw and the transmembrane protein Rho, are involved in RPTK signalling.
引用
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页码：260 / 266
页数：7
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