EFFECTS OF OKADAIC ACID ON INSULIN-SECRETION FROM RAT ISLETS OF LANGERHANS

被引：34
|
作者：
RATCLIFF, H
JONES, PM
机构：
[1] Biomedical Sciences Division, King's College London, London
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1175卷 / 02期
基金：
英国医学研究理事会;
关键词：
INSULIN SECRETION; OKADAIC ACID; PROTEIN PHOSPHATASE; (ISLET OF LANGERHANS);
D O I：
10.1016/0167-4889(93)90022-H
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have studied the effects of the phosphatase inhibitor, okadaic acid. on insulin secretion and protein phosphorylation in intact and electrically permeabilized pancreatic islets. Okadaic acid inhibited glucose-induced insulin secretion from intact islets, although this effect was probably non-specific since similar effects were obtained using 1-nor-okadaone, a virtually inactive analogue of okadaic acid. In permeabilized islets, okadaic acid enhanced basal and cyclic-AMP-induced insulin secretion and protein phosphorylation. These results indicate that protein phosphatases may play a role in the regulation of insulin release.
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页码：188 / 191
页数：4
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