LYSOPHOSPHATIDIC ACID INDUCES INWARD CURRENTS IN XENOPUS-LAEVIS OOCYTES - EVIDENCE FOR AN EXTRACELLULAR SITE OF ACTION

被引：61

作者：

FERNHOUT, BJH

DIJCKS, FA

MOOLENAAR, WH

RUIGT, GSF

机构：

[1] ORGANON INT BV,CNS PHARMACOL DEPT,POB 20,5340 BH OSS,NETHERLANDS

[2] NETHERLANDS CANC INST,DIV CELLULAR BIOCHEM,1066 CX AMSTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 213卷 / 02期

关键词：

LYSOPHOSPHATIDIC ACID; OOCYTES XENOPUS-LAEVIS;

D O I：

10.1016/0014-2999(92)90698-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lysophosphatidic acid (LPA) is a naturally occurring phospholipid that can elicit platelet aggregation, smooth muscle contraction and, in fibroblasts, cell proliferation. We now report that LPA in nanomolar concentrations evokes an inward current in native, defolliculated Xenopus laevis oocytes. Extracellular application of LPA from a pressure pipette to the surface of the oocyte induced an immediate response. In contrast, intracellular injection of the same amount of LPA failed to elicit a response. These data suggest the existence of a Ca2+-mobilizing, endogeneous LPA receptor in the Xenopus laevis oocyte cell membrane.

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页码：313 / 315

页数：3

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