8-SUBSTITUTED 5-[(AMINOALKYL)AMINO]-6H-V-TRIAZOLO[4,5,1-DE]ACRIDIN-6-ONES AS POTENTIAL ANTINEOPLASTIC AGENTS - SYNTHESIS AND BIOLOGICAL-ACTIVITY

被引：92

作者：

CHOLODY, WM ^{[1
]}

MARTELLI, S ^{[1
]}

KONOPA, J ^{[1
]}

机构：

[1] UNIV CAMERINO,DEPT CHEM SCI,I-62032 CAMERINO,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1990年 / 33卷 / 10期

关键词：

D O I：

10.1021/jm00172a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 8-substituted 5-[(aminoalkyl)amino]-6H-u-triazolo[4,5,l-de]acridin-6-ones (2), structurally related to the imidazoacridinones (1), was synthesized and tested for cytotoxic and antineoplastic activity. Preliminary biological results indicated that the 8-OH derivatives possess the highest antitumor activity. No relationship has been found between the nature of the C-8 substituent and antitumor activity. © 1990, American Chemical Society. All rights reserved.

引用

页码：2852 / 2856

页数：5

共 26 条

[1] POTENTIAL ANTITUMOR AGENTS .50. INVIVO SOLID-TUMOR ACTIVITY OF DERIVATIVES OF N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE [J].