Effect of Statins on the Mortality of Bacteremic Patients: A Systematic Review and Meta-analysis of Clinical Trials

被引：9
|
作者：
Shrestha, Pragya [1 ]
Poudel, Dilli R. [2 ]
Pathak, Ranjan [2 ]
Ghimire, Sushil [2 ]
Dhital, Rashmi [3 ]
Aryal, Madan R. [2 ]
Mahmood, Maryam [2 ]
Karmacharya, Paras [2 ]
机构：
[1] Nanjing Med Univ, Dept Internal Med, Nanjing, Jiangsu, Peoples R China
[2] Reading Hlth Syst, Dept Internal Med, W Reading, PA 19611 USA
[3] Univ Coll Med Sci, Dept Internal Med, Bhairahawa, Nepal
来源：
NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES | 2016年 / 8卷 / 06期
关键词：
Bacteremia; infection; inflammation; mortality;
D O I：
10.4103/1947-2714.185034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. Aims: We examined the effect of statins on the mortality of bacteremia patients. Materials and Methods: Major databases were searched for the pertinent clinical trials. Results: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin. Conclusions: There may be a potential role of statins in similar inflammatory and infective conditions.
引用
收藏
页码：250 / +
页数：2
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