Topical administration of tranexamic acid in total hip arthroplasty: A meta-analysis of Randomized Controlled Trials

被引:10
作者
Xu, Xingming [1 ]
Xiong, Shan [1 ]
Wang, Zhenyu [1 ]
Li, Xiaofeng [1 ]
Liu, Wei [1 ]
机构
[1] Nanchang Univ, Affiliated Hosp 1, Dept Orthopaed, Nanchang 330006, Jiangxi, Peoples R China
关键词
Topical administration; tranexamic acid; total hip arthroplasty; intra-articular; meta-analysis;
D O I
10.5582/ddt.2015.01018
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tranexamic acid (TXA) is an antifibrinolytic drug which has been widely used in many areas of surgery. The purpose of our meta-analysis was to review randomized controlled trials (RCT) of the effectiveness and safety of topical TXA treatment in reducing total blood loss and transfusion rate for patients undergoing primary total hip arthroplasty (THA). A literature search was undertaken. Five eligible reports match the inclusion and exclusion standard. The topical administration of TXA groups revealed lower total blood loss(mean difference - 347ml, 95% CI, - 411 to - 282 mL; p < 0.00001) and transfusion rate (OR, 0.23 (p < 0.00001; 95% CI, 0.14-0.38)) compared with control groups. Meanwhile there was no statistically significant difference in the risk of developing thromboembolic events (OR, 1.64 (95% CI, 0.39-6.97); p = 0.5). Topical administration of TXA could significantly reduce total blood loss and transfusion requirements in primary THA, without increased thromboembolic complications.
引用
收藏
页码:173 / 177
页数:5
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