Stem memory T cells (TSCM)-their role in cancer and HIV immunotherapies

被引：64

作者：

Flynn, Jacqueline K. ^{[1
,2
]}

Gorry, Paul R. ^{[1
,2
,3
]}

机构：

[1] Ctr Biomed Res, Burnet Inst Melbourne, 85 Commercial Rd, Melbourne, Vic, Australia

[2] Monash Univ, Dept Infect Dis, Melbourne, Vic, Australia

[3] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic, Australia

来源：

CLINICAL & TRANSLATIONAL IMMUNOLOGY | 2014年 / 3卷

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/cti.2014.16

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Stem memory T cells (TSCM) have been described in mice, non-human primates and in humans, constituting approximately 2-4% of the total CD4(+) and CD8(+) T-cell population in the periphery. TSCM represent the earliest and long-lasting developmental stage of memory T cells, displaying stem cell-like properties, and exhibiting a gene profile between naive and central memory T cells. Their self-renewal capacity and long-term survival has sparked interest in the cancer and human immunodeficiency virus (HIV) fields. How and when the formation of TSCM occurs during the immune response to pathogens and the therapeutic potential of these cells are currently being investigated. This review will explore the potential role of TSCM to be used as, or targeted by, immunotherapies and vaccines for treatment of cancer and HIV.

引用

页数：7

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