Design considerations for targeted optical contrast agents

被引：67

作者：

Lee, Jeong Heon ^{[1
,2
]}

Park, Gwangli ^{[1
,2
]}

Hong, Gloria H. ^{[1
,2
]}

Choi, Jungmun ^{[1
,2
]}

Choi, Hak Soo ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Dept Med, Div Hematol Oncol, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Beth Israel Deaconess Med Ctr, Ctr Mol Imaging, Boston, MA 02215 USA

来源：

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | 2012年 / 2卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Near-infrared imaging; optical imaging; targeted contrast agent; biodistribution;

D O I：

10.3978/j.issn.2223-4292.2012.12.04

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Optical fluorescence imaging with the right combination of imaging modality and targeted contrast agents offers tremendous improvement in intraoperative imaging and clinical output (i.e., image-guided cancer surgery). Therefore, it is of paramount importance to gain an in-depth knowledge in the design of targeted contrast agents to meet clinical requirements. Currently, there are several clinically approved contrast agents available; however, none perform optimally in vivo by providing optimum sensitivity, stability, specificity, and safety for target imaging, diagnosis, and therapy. In this review, we discuss basic design considerations for targeted contrast agents in terms of optical and physicochemical properties, biological and physiological interactions, and biodistribution and targeting.

引用

页码：266 / 273

页数：8

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