EFFECTS OF L-DOPA METABOLITES AT A DOPAMINE RECEPTOR SUGGEST A BASIS FOR ON-OFF EFFECT IN PARKINSONS-DISEASE

被引：47

作者：

DOUGAN, D ^{[1
]}

WADE, D ^{[1
]}

MEARRICK, P ^{[1
]}

机构：

[1] UNIV NEW S WALES,ST VINCENTS HOSP,DEPT CLIN PHARMACOL,SYDNEY,NEW WALES,AUSTRALIA

来源：

NATURE | 1975年 / 254卷 / 5495期

关键词：

D O I：

10.1038/254070a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：70 / 72

页数：3

共 13 条

[1] DRUGS AFFECTING MOVEMENT DISORDERS [J].

BARBEAU, A .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1974, 14 :91-113

[2] ON-OFF PHENOMENA RELATED TO HIGH PLASMA LEVODOPA [J].

CLAVERIA, LE ;

CALNE, DB ;

ALLEN, JG .

BRITISH MEDICAL JOURNAL, 1973, 2 (5867) :641-643

[3] SOME NEWER METABOLIC CONCEPTS IN TREATMENT OF PARKINSONISM [J].

COTZIAS, GC ;

STECK, AJ ;

DUBY, SE ;

PAPAVASILIOU, PS ;

GINOS, JZ .

NEUROLOGY, 1972, 22 (05) :82-+

[4]

DOUGAN D F H, 1970, Comparative and General Pharmacology, V1, P33, DOI 10.1016/0010-4035(70)90006-6

[5] ON-OFF PHENOMENON WITH LEVODOPA THERAPY IN PARKINSONISM - CLINICAL AND PHARMACOLOGIC CORRELATIONS AND EFFECT OF INTRAMUSCULAR PYRIDOXINE [J].

FAHN, S .

NEUROLOGY, 1974, 24 (05) :431-441

[6]

HEIKKILA R, 1971, J PHARMAC EXP THER, V179, P150

[7]

HORNYKIE.O, 1973, FED PROC, V32, P183

[8] EFFECTS OF DOPAMINE-LIKE DRUGS ON RAT STRIATAL ADENYL-CYCLASE HAVE IMPLICATIONS FOR CNS DOPAMINE RECEPTOR TOPOGRAPHY [J].

MILLER, R ;

HORN, A ;

IVERSEN, L ;

PINDER, R .

NATURE, 1974, 250 (5463) :238-241

[9] TETRAHYDROISOQUINOLINE ALKALOIDS - IN-VIVO METABOLITES OF L-DOPA IN MAN [J].

SANDLER, M ;

CARTER, SB ;

HUNTER, KR ;

STERN, GM .

NATURE, 1973, 241 (5390) :439-443

[10]

SHEPPARD H, 1974, RES COMMUN CHEM PATH, V8, P527

← 1 2 →