MICROTUBULE DYNAMICS - TAKING AIM AT A MOVING TARGET

被引：205

作者：

WILSON, L

JORDAN, MA

机构：

来源：

CHEMISTRY & BIOLOGY | 1995年 / 2卷 / 09期

关键词：

D O I：

10.1016/1074-5521(95)90119-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antitumor drugs of the vinca alkaloid and taxane classes function by suppressing the dynamics of microtubules in spindles, blocking cell division at metaphase. The drugs bind to various sites on the tubulin dimer and at different positions within the microtubule, suggesting that there are many unexplored targets for the design of novel drugs of this type.

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页码：569 / 573

页数：5

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