Three cases of clinical or preclinical Cushing's syndrome due to adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia: Pituitary-adrenocortical function and immunohistochemistry

被引：6

作者：

Murakami, O

Satoh, F

Takahashi, K

Totsune, K

Sone, M

Ohneda, M

Abe, K

Suzuki, T

Sasano, H

Mouri, T

机构：

[1] Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai

[2] Second Department of Pathology, Tohoku University School of Medicine, Sendai

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 11期

关键词：

cortisol; corticotropin-releasing hormone; dexamethasone; steroidogenic cytochromes P-450; 3 beta-hydroxysteroid dehydrogenase; gastric inhibitory polypeptide;

D O I：

10.2169/internalmedicine.34.1074

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed pituitary-adrenocortical function test and analysis of plasma steroids in three cases of adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia, and examined the plasma cortisol response to meal and oral glucose in two cases, On pathological examination, nodules were mainly composed of clear cells and some nests of compact cells were observed. Immunohistochemistry of steroidogenic enzymes showed positive P-450(C17) only in the compact cells and positive 3 beta-hydroxysteroid dehydrogenase only in the clear cells, These cases were similar to clinical or preclinical Cushing's syndrome due to adenoma in both pituitary-adrenocortical function and plasma steroid patterns, but different from adenoma cases in the distribution of steroidogenic enzymes.

引用

页码：1074 / 1081

页数：8

共 15 条

[1] Kirschner M.A., Powell R.D., Lipsett M.B., Cushing's syndrome: Nodular cortical hyperplasia of adrenal glands with clinical and pathological features suggesting adrenocortical tumor, J Clin Bndocrinol Metab, 24, (1964)
[2] Malchoff C.D., Rosa J., DeBold C.R., Et al., Adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia: an unusual cause of Cushing's syndrome, J Clin Endocrinol Metab, 68, (1989)
[3] Aiba M., Hirayama A., Iri H., Et al., Adrenocorticotropic hormone-independent bilateral adrenocortical macronodular hyperplasia as a distinct subtype of Cushing's syndrome, Am J Clin Pathol, 96, (1991)
[4] Lacroix A., Bolte E., Tremblay L., Et al., Gastric inhibitory polypeptidedependent cortisol hypersecretion, N Engl J Med, 327, (1992)
[5] Reznic Y., Allalli-Zerah V., Chayvialle J.A., Et al., Food-dependent Cushing's syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide, N Engl J Med, 327, (1992)
[6] Sasano H., White P.C., News M.I., Sasano N., Immunohistochemical localization of cytochrome P-450C21 in human adrenal cortex and its relation to endocrine function, Human Pathol, 19, (1988)
[7] Sasano H., Okamoto M., Sasano N., Immunohistochemical study of cytochrome, P-450 11 β-hydroxylase in human adrenal cortex with mineraloand glucocorticoid excess, Virchows Arch, 413, A, (1988)
[8] Sasano H., Sasano N., Okamoto M., Immunohistochemical demonstration of cholesterol side-chain cleavage cytochrome P-450 in bovine and human adrenal, Pathol Res Pract, 184, (1989)
[9] Sasano H., Mason J.I., Sasano N., Immunohistochemical study of cytochrome P-45017α in human adrenal disorders, Human Pathol, 20, (1989)
[10] Sasano H., Mason J.I., Sasano N., Nagura H., Immunolocalization of 3β-hydroxysteroid dehydrogenase in human adrenal cortex and in its disorders, Endocrine Pathol, 1, (1990)

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