A FIBROBLAST ELONGATION-FACTOR PURIFIED FROM COLON-CARCINOMA CELLS SHARES SEQUENCE IDENTITY WITH TIMP-1

被引：17

作者：

AGREZ, MV

MELDRUM, CJ

SIM, ATR

AEBERSOLD, RH

CLARK, IM

CAWSTON, TE

BURNS, GF

机构：

[1] UNIV BRITISH COLUMBIA,BIOMED RES CTR,VANCOUVER,BC,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT BIOCHEM,VANCOUVER,BC,CANADA

[3] ADDENBROOKES HOSP,RHEUMATOL UNIT,CAMBRIDGE,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 206卷 / 02期

关键词：

D O I：

10.1006/bbrc.1995.1084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously reported that human colon cancer cells secrete a factor(s) which induces elongation of colon fibroblasts in vitro. Isolation of this factor led to the identification of a 55kD protein with fibroblast stretching activity. Two internal amino acid sequences identified in this protein (YEI; GFQALGDAADI) share complete homology with tissue inhibitor of metalloproteinase (TIMP-1). (C) 1995 Academic Press, Inc.

引用

收藏

页码：590 / 600

页数：11

相关论文

共 14 条

[1] INTERNAL AMINO-ACID SEQUENCE-ANALYSIS OF PROTEINS SEPARATED BY ONE-DIMENSIONAL OR TWO-DIMENSIONAL GEL-ELECTROPHORESIS AFTER INSITU PROTEASE DIGESTION ON NITROCELLULOSE [J].

AEBERSOLD, RH ;

LEAVITT, J ;

SAAVEDRA, RA ;

HOOD, LE ;

KENT, SBH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (20) :6970-6974

[2] THE ROLE OF COLON FIBROBLASTS IN MALIGNANT LARGE-BOWEL OBSTRUCTION - AN EXPERIMENTAL INVITRO MODEL [J].

AGREZ, MV ;

CHUA, FK .

BRITISH JOURNAL OF CANCER, 1990, 62 (04) :567-572

[3] EXTRACELLULAR MATERIAL SECRETED BY HUMAN COLONIC ADENOCARCINOMA CELL-LINES PROMOTES SPREADING IN SERUM-FREE MEDIUM AND INDUCES NEURITE OUTGROWTH OF PC-12 CELLS [J].

BELLOT, F ;

LUIS, J ;

ELBATTARI, A ;

SECCHI, J ;

CAU, P ;

MARVALDI, J ;

PICHON, J .

INTERNATIONAL JOURNAL OF CANCER, 1985, 36 (05) :609-615

[4] PRIMARY STRUCTURE AND CDNA CLONING OF HUMAN FIBROBLAST COLLAGENASE INHIBITOR [J].

CARMICHAEL, DF ;

SOMMER, A ;

THOMPSON, RC ;

ANDERSON, DC ;

SMITH, CG ;

WELGUS, HG ;

STRICKLIN, GP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2407-2411

[5] RAPID PURIFICATION OF TISSUE INHIBITOR OF METALLOPROTEINASES FROM HUMAN-PLASMA AND IDENTIFICATION AS A GAMMA-SERUM PROTEIN [J].

CAWSTON, TE ;

NOBLE, DN ;

MURPHY, G ;

SMITH, AJ ;

WOODLEY, C ;

HAZLEMAN, B .

BIOCHEMICAL JOURNAL, 1986, 238 (03) :677-682

[6] SEQUENCE OF HUMAN-TISSUE INHIBITOR OF METALLOPROTEINASES AND ITS IDENTITY TO ERYTHROID-POTENTIATING ACTIVITY [J].

DOCHERTY, AJP ;

LYONS, A ;

SMITH, BJ ;

WRIGHT, EM ;

STEPHENS, PE ;

HARRIS, TJR ;

MURPHY, G ;

REYNOLDS, JJ .

NATURE, 1985, 318 (6041) :66-69

[7]

GRIMMOND HE, 1989, CANCER BIOCHEM BIOPH, V10, P353

[8] CYTOKINE-INDUCED PSEUDOPODIAL PROTRUSION IS COUPLED TO TUMOR-CELL MIGRATION [J].

GUIRGUIS, R ;

MARGULIES, I ;

TARABOLETTI, G ;

SCHIFFMANN, E ;

LIOTTA, L .

NATURE, 1987, 329 (6136) :261-263

[9]

HOWARD EF, 1976, CANCER RES, V36, P4543

[10] CANCER METASTASIS AND ANGIOGENESIS - AN IMBALANCE OF POSITIVE AND NEGATIVE REGULATION [J].

LIOTTA, LA ;

STEEG, PS ;

STETLERSTEVENSON, WG .

CELL, 1991, 64 (02) :327-336