INTERACTION OF SUBSTANCE-P, COMPOUND-48/80 AND MASTOPARAN WITH THE ALPHA-SUBUNIT C-TERMINUS OF G-PROTEIN

被引：176

作者：

MOUSLI, M

BRONNER, C

BOCKAERT, J

ROUOT, B

LANDRY, Y

机构：

[1] UNIV STRASBOURG 1,NEUROIMMUNOPHARMACOL LAB,F-67070 STRASBOURG,FRANCE

[2] CTR PHARMACOL ENDOCRINOL,CNRS,INSERM,MONTPELLIER,FRANCE

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 04期

关键词：

Antibody; Compound; 48; 80; G proteins; Mastoparan; Pertussis toxin; Substance P;

D O I：

10.1016/0165-2478(90)90207-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus of their α subunits prevented the increase in GTPase activity induced by substance P, compound 48 80 and mastoparan. These results suggest that these mast cell secretagogues activate G proteins directly via an interaction with the C-terminus of α subunits of G proteins by mimicking the agonist-liganded receptors. © 1990.

引用

页码：355 / 357

页数：3

共 6 条

[1] ROLE OF THE N-TERMINAL ARGININE IN THE HISTAMINE-RELEASING ACTIVITY OF SUBSTANCE-P, BRADYKININ AND RELATED PEPTIDES [J].