THE EFFECTS OF LEVONORGESTREL, DESOGESTREL AND GESTODENE ON THE PULSATILE RELEASE OF LUTEINIZING-HORMONE IN ORAL-CONTRACEPTIVE USERS

被引：2
作者：
HEMRIKA, DJ
SLAATS, EH
KENNEDY, JC
ROBLESKORSEN, TJMD
SCHOEMAKER, J
机构：
[1] Department of Reproductive Endocrinology and Fertility, Free University Hospital, Amsterdam
[2] Department of Clinical Chemistry, O. L. Vrouwe Gasthuis, Free University Hospital, Amsterdam
来源：
GYNECOLOGICAL ENDOCRINOLOGY | 1993年 / 7卷 / 03期
关键词：
ORAL CONTRACEPTIVES; PROGESTOGENS; LUTEINIZING HORMONE; PULSATILE RELEASE; PITUITARY; STEROID FEEDBACK;
D O I：
10.3109/09513599309152502
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The dynamics of luteinizing hormone (LH) and follicle stimulating hormone (FSH) release were investigated in 60 long-term oral contraceptive (OC) users. Five different types of OC, all containing the same amount of estrogens were studied: three monophasic preparations containing levonorgestrel, desogestrel and gestodene, respectively, and two triphasic formulations, containing levonorgestrel or gestodene. Thirteen healthy, normally cycling volunteers served as controls. Blood sampling was performed at 10-min intervals during a 6-h period to determine the pulsatile release of LH. LH and FSH were measured using a sensitive immunoradiometric assay. Pulse patterns were classified on the basis of the overall LH level, as well as on the character of the LH pulses, according to both frequency and amplitude characteristics. Pulsatile LH release was maintained during OC use. After the 7-day pill-free interval, FSH levels as well as the LH pulse patterns were comparable to those of early follicular-phase controls. FSH levels and FSH release in response to a gonadotropin releasing hormone (GnRH) challenge were profoundly suppressed in all OC users, as early as day 8 of the pill cycle. LH release during the pill cycle was characterized by either a low frequency (median 1 pulse/6 h), high amplitude (median 2.5 IU/l) pulse pattern or by a pattern of low-amplitude pulses (median 0.2 IU/l) and low basal LH levels (median 0.2 IU/l). The distribution of these pulse patterns showed marked differences between different OC preparations and depended on both the type and dose regimen of the gestagenic component of the OC.
引用
收藏
页码：191 / 200
页数：10
相关论文
共 30 条
  • [1] Filicori M., Santoro N., Merriam G.R., Crowley W.F., Characterization of the physiological pattern of episodic gonadotropin secretion throughout the human menstrual cycle, J. Clin. Endocrinol. Metab., 62, pp. 1136-1144, (1986)
  • [2] Reame N., Sauder S.E., Kelch P., Marshall J.C., Pulsatile gonadotropin secretion during the human menstrual cycle: Evidence for altered frequency of gonadropin-releasing hormone secretion, J. Clin. Endocrinol. Metab., 59, pp. 328-337, (1984)
  • [3] Marshall J.C., Dalkin A.C., Haisenleder J., Paul S.J., Ortolano G.A., Kelch R.P., Gonadotropin-releasing hormone pulses: Regulators of gonadotropin synthesis and ovulatory cycles, Rec. Prog. Horm. Res., 47, pp. 155-189, (1991)
  • [4] Santoro N., Filicori M., Crowley W.F., Hypogonadotropic disorders in men and women: Diagnosis and therapy with pulsatile gonadotropin-releasing hormone, Endocr. Rev., 7, pp. 11-23, (1986)
  • [5] Burger C.W., Korsen T., Van Kessel H., Van Dop P.A., Caron F.J.M., Schoemaker J., Pulsatile luteinizing hormone patterns in the follicular phase of the menstrual cycle, polycystic ovarian disease and non-PCOD secondary amenorrhea, J. Clin. Endocrinol. Metab., 61, pp. 1126-1132, (1985)
  • [6] Plant T.M., Gonadal regulation of hypothalamic gonadotropin-releasing hormone release in primates, Endocr. Rev., 7, pp. 75-88, (1986)
  • [7] Crowley W.F., Filicori M., Spratt D.I., Santoro N.F., The physiology of gonadotropin-releasing hormone (GnRH) secretion in men and women, Rec. Prog. Horm. Res., 41, pp. 473-531, (1985)
  • [8] Schasison G., Couzinet B., Steroid control of gonadotropin secretion. J, Steroid. Biochem. Mol. Biol., 40, pp. 417-420, (1991)
  • [9] Van der Spuy Z.M., Sohnius U., Pienaar C.A., Schall R., Gonadotropin and estradiol secretion during the week of placebo therapy in oral contraceptive pill users, Contraception, 42, pp. 597-609, (1990)
  • [10] Jaakola T., Dingm Y.Q., Kellokumpu-Lehtinen P., Valavaara R., Martikainen H., Tapanainen J., The ratios of serum bioactive/im-munoreactive luteinizing hormone and follicle-stimulating hormone in various clinical conditions with increased and decreased gonadotropin secretion: re-evaluation by a highly sensitive immuno-metric assay, J. Clin. Endocrinol. Metab., 70, pp. 1496-1505, (1990)
123