A LONG-TERM STUDY OF INTERSTITIAL LUNG-DISEASE IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引:105
作者
WEINRIB, L
SHARMA, OP
QUISMORIO, FP
机构
[1] UNIV SO CALIF,SCH MED,DIV RHEUMATOL & IMMUNOL,HMR-711,2011 ZONAL AVE,LOS ANGELES,CA 90033
[2] UNIV SO CALIF,SCH MED,DIV PULM MED,LOS ANGELES,CA 90033
[3] UNIV SO CALIF,LOS ANGELES CTY MED CTR,LOS ANGELES,CA 90033
关键词
Pulmonary fibrosis; systemic lupus erythematosus;
D O I
10.1016/0049-0172(90)90094-V
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical course of chronic diffuse interstitial lung disease (ILD) was studied in 14 patients with SLE. The mean duration of follow-up was 7.3 years. All patients had dyspnea on exertion, pleuritic chest pain, chronic cough, and basilar rales. Chest roentgenogram showed diffuse or basilar infiltrates, pleural disease, and elevation of both diaphragms. Systemic corticosteroids were given early in the course of the illness for lung involvement and multisystem disease. Diffusing capacity for carbon monoxide (DLCO) and inspiratory vital capacity (IVC) improved or remained unchanged in the majority of patients. Respiratory complaints improved in all patients; however, two patients died of pulmonary fibrosis and another died of bacterial pneumonia. Alveolar septal deposits of immunoglobulins and complement were found. This study showed that while variability existed among individual subjects, the clinical progression of ILD was slow and tended to improve or stabilize with time. © 1990.
引用
收藏
页码:48 / 56
页数:9
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