Impact of neuropsychiatric symptoms on caregiver burden in patients with Alzheimer's disease

被引：35

作者：

Fischer, Corinne Eleanor ^{[1
]}

Ismail, Zahinoor ^{[2
]}

Schweizer, Tom A. ^{[1
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Room 17044 CC Wing,30 Bond St, Toronto, ON M5B 1W8, Canada

[2] Univ Calgary, Dept Psychiat, Calgary, AB T2N 2T9, Canada

来源：

NEURODEGENERATIVE DISEASE MANAGEMENT | 2012年 / 2卷 / 03期

关键词：

D O I：

10.2217/NMT.12.19

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuropsychiatric symptoms (NPS) are very common amongst patients with Alzheimer's disease and contribute significantly to caregiver burden. Different NPS may contribute differently to caregiver burden. This has important implications for targeting treatment. Medline was searched using the keywords 'caregiver burden', 'BPSD', 'behavioral problems', 'Alzheimer's disease', 'dementia' and 'dementia of the Alzheimer type'. After an extensive search, 14 papers were identified. Caregiver burden and related quality-oflife measures were significantly associated with NPS in all studies. When compared with other factors, NPS had a stronger association than demographic and cognitive factors and a similar association with functional impairment. Psychotic symptoms were consistently associated with increased caregiver burden compared with other NPS. Pharmacological and nonpharmacological interventions should focus on addressing the NPS that are most associated with increased caregiver burden.

引用

页码：269 / 277

页数：9

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