Stem cells for urinary tract regeneration

被引：10

作者：

Bajek, Anna ^{[1
]}

Drewa, Tomasz ^{[1
,2
]}

Joachimiak, Romana ^{[1
]}

Marszalek, Andrzej ^{[3
,4
]}

Gagat, Maciej ^{[5
]}

Grzanka, Alina ^{[5
]}

机构：

[1] Nicolaus Copernicus Univ, Dept Tissue Engn, 24 Karlowicza St, PL-85090 Bydgoszcz, Poland

[2] Inst Oncol, Dept Urol, Bydgoszcz, Poland

[3] Nicolaus Copernicus Univ, Dept Clin Pathomorphol, Bydgoszcz, Poland

[4] Univ Med Sci, Dept Clin Pathomorphol, Poznan, Poland

[5] Nicolaus Copernicus Univ, Dept Histol & Embryol, Bydgoszcz, Poland

来源：

CENTRAL EUROPEAN JOURNAL OF UROLOGY | 2012年 / 65卷 / 01期

关键词：

stem cells; urinary bladder; bladder cancer; urinary sphincter; urinary incontinence;

D O I：

10.5173/ceju.2012.01.art2

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Regeneration of the urinary bladder is a complicated task, due to organ dimensions and diseases (cancer, interstitial cystitis) when autologous bladder cells cannot be used. Cancer is the most frequent indication for bladder removal (cystectomy). Stem cells can be used with the guarantee of the sufficient cell number for the in vitro construction of the urinary bladder wall. Tissue engineering techniques hold great promise for regeneration of dysfunctional urinary sphincter. Denervation following surgical procedures or injuries results in weakness of the urethral sphincter and stress urinary incontinence. Injectable therapies and the potential of stem cells for sphincter restoration was presented in this review. The aim of this review was to present possibilities of urinary bladder regeneration with the use of stem cells and tissue engineering techniques.

引用

页码：7 / 10

页数：4

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