INITIATION AT CLOSELY SPACED REPLICATION ORIGINS IN A YEAST CHROMOSOME

被引:88
作者
BREWER, BJ
FANGMAN, WL
机构
[1] Department of Genetics SK-50, University of Washington, Seattle
关键词
D O I
10.1126/science.8259517
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Replication of eukaryotic chromosomes involves initiation at origins spaced an average of 50 to 100 kilobase pairs. In yeast, potential origins can be recognized as autonomous replication sequences (ARSs) that allow maintenance of plasmids. However, there are more ARS elements than active chromosomal origins. The possibility was examined that close spacing of ARSs can lead to inactive origins. Two ARSs located 6.5 kilobase pairs apart can indeed interfere with each other. Replication is initiated from one or the other ARS with equal probability, but rarely (<5%) from both ARSs on the same DNA molecule.
引用
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页码:1728 / 1731
页数:4
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