ASSOCIATION OF TRANSCRIPTION FACTOR APRF AND PROTEIN-KINASE JAK1 WITH THE INTERLEUKIN-6 SIGNAL TRANSDUCER GP130

被引：747

作者：

LUTTICKEN, C

WEGENKA, UM

YUAN, JP

BUSCHMANN, J

SCHINDLER, C

ZIEMIECKI, A

HARPUR, AG

WILKS, AF

YASUKAWA, K

TAGA, T

KISHIMOTO, T

BARBIERI, G

PELLEGRINI, S

SENDTNER, M

HEINRICH, PC

HORN, F

机构：

[1] RHEIN WESTFAL TH AACHEN,INST BIOCHEM,PAUWELSSTR 30,D-52057 AACHEN,GERMANY

[2] COLUMBIA UNIV COLL PHYS & SURG,DEPT MED,NEW YORK,NY 10032

[3] UNIV BERN,CLIN & EXPTL CANC RES LAB,CH-3004 BERN,SWITZERLAND

[4] ROYAL MELBOURNE HOSP,LUDWIG INST CANC RES,PARKVILLE,VIC 3050,AUSTRALIA

[5] TOSOH CORP,BIOTECHNOL RES LAB,KANAGAWA 252,JAPAN

[6] OSAKA UNIV,INST MOLEC & CELLULAR BIOL,SUITA,OSAKA 565,JAPAN

[7] OSAKA UNIV,SCH MED,DEPT MED 3,SUITA,OSAKA 565,JAPAN

[8] INST PASTEUR,INSERM,U276,F-75724 PARIS 15,FRANCE

[9] MAX PLANCK INST PSYCHIAT,D-82152 MARTINSRIED,GERMANY

来源：

SCIENCE | 1994年 / 263卷 / 5143期

关键词：

D O I：

10.1126/science.8272872

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3alpha (ISGF-3alpha). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3alpha p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.

引用

页码：89 / 92

页数：4

共 32 条

[1] IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].