MOLECULAR-INTERACTIONS IN FIBRINOLYSIS, SEARCH FOR NEW PLASMINOGEN ACTIVATORS (A REVIEW)

The review summarizes the data on the kinetics of plasminogen activation by plasminogen activators (PA) of the tissue and the urokinase types; analyzes the mechanisms of this interaction in the presence of fibrin; demonstrates the regulatory role of the latter in plasminogen activation through direct interaction with the tissue-type PA and indirect interaction with the urokinase-type PA; reveals the functions of these PA and presents experimental and clinical data on their mutually complementary action in eliminating thrombi; establishes the criteria of PA thrombolytic efficacy; assesses the new fibrinolytics derived by chemical modification, recombinant DNA technology, or combinations thereof; demonstrates the prospects of new-generation PA and the importance of combined thrombolytics; and considers the results of molecular, physiological, and clinical studies concerned with PA therapy.