A NOVEL METHOD FOR THE DETERMINATION OF IONIZATION SITES IN POLYFUNCTIONAL ACIDS AND BASES BY NMR RELAXATION RATE MEASUREMENTS

被引：22

作者：

BAGNO, A

COMUZZI, C

SCORRANO, G

机构：

[1] Centro CNR Meccanismi Reazioni Organiche, Dipartimento di Chimica Organica, Università di Padova, 35131 Padova

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1993年 / 03期

关键词：

D O I：

10.1039/p29930000283

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method which enables one to determine the site of ionization in polyfunctional acids and bases is presented. The method is based on the changes in NMR longitudinal relaxation time (T1) of all the nuclei potentially involved, because addition or removal of a proton from a given nuclear site will affect its T1 in a predictable way. This approach is shown to be effective even under conditions of fast exchange of the acidic proton on a range of monofunctional models (Me3N and MeNH2, studied by N-14 and N-15 NMR spectroscopy) and some polyfunctional bases (MeCONMe2, MeCSNMe2, 4-aminopyridine, by N-14 and O-17 NMR spectroscopy).

引用

页码：283 / 284

页数：2

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