PHARMACOKINETICS OF FLUVOXAMINE MALEATE AFTER INCREASING SINGLE ORAL DOSES IN HEALTHY-SUBJECTS

The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100 mg fluvoxamine maleate was studied in a three-way cross-over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For dose-proportionality, AUC, and C(max)-dose relationships were evaluated by linear regression. Plasma concentrations increased in a linear dose-dependent manner in the dose range between 25 and 100 mg; t1/2 and T(max) showed no significant differences among treatments. Fluvoxamine was well tolerated.