NEW MODEL FOR 70-KDA HEAT-SHOCK PROTEINS POTENTIAL MECHANISMS OF FUNCTION

被引：28
|
作者：
TSANG, TC
机构：
[1] Department of Microbiology and Immunology, College of Medicine, University of Arizona, Tucson
来源：
FEBS LETTERS | 1993年 / 323卷 / 1-2期
关键词：
HSP-70; CYTOSKELETON; ACTIN; CROSS-LINKER; TARGETING SEQUENCE; MOLECULAR CHAPERONE;
D O I：
10.1016/0014-5793(93)81435-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 70 kDa family of heat-shock proteins (hsp 70s and hsc 70s) can facilitate protein transport to several organelles. This process is thought to involve electrostatic interactions between hsp 70s and the cellular protein targeting sequences. Analysis of the highly conserved structural and functional properties of the hsp 70 family indicated that they may cross-link cellular proteins to the actin microfilament network. Direct experimental support for this hypothesis was provided by the finding that hsp 70 is constitutively bound to actin through hydrophobic interactions. The cross-linker model may provide an explanation for the mechanism by which the cytoskeletal matrix could mediate various cellular processes.
引用
收藏
页码：1 / 3
页数：3
相关论文
共 50 条
  • [31] A disulfide bridge mediated by cysteine 574 is formed in the dimer of the 70-kDa heat shock protein
    Nemoto, Takayuki K.
    Fukuma, Yutaka
    Itoh, Hideaki
    Takagi, Takashi
    Ono, Toshio
    JOURNAL OF BIOCHEMISTRY, 2006, 139 (04) : 677 - 687
  • [32] Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides
    McCallister, Chelsea
    Kdeiss, Brianna
    Oliverio, Ryan
    Nikolaidis, Nikolas
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 472 (01) : 270 - 275
  • [33] THE ROLES OF HEAT-SHOCK PROTEINS IN PLANTS
    VIERLING, E
    ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1991, 42 : 579 - 620
  • [34] Chaperone function and mechanism of small heat-shock proteins
    Fu, Xinmiao
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2014, 46 (05) : 347 - 356
  • [35] Levels of 70-kDa heat shock protein through the cell cycle in several mammalian cell lines
    Hang, HY
    Fox, MH
    CYTOMETRY, 1996, 25 (04): : 367 - 373
  • [36] Microsporidia, amitochondrial protists, possess a 70-kDa heat shock protein gene of mitochondrial evolutionary origin
    Peyretaillade, E
    Broussolle, V
    Peyret, P
    Méténier, G
    Gouy, M
    Vivarès, CP
    MOLECULAR BIOLOGY AND EVOLUTION, 1998, 15 (06) : 683 - 689
  • [37] Interaction between Arabidopsis heat shock transcription factor 1 and 70 kDa heat shock proteins
    Kim, BH
    Schöffl, F
    JOURNAL OF EXPERIMENTAL BOTANY, 2002, 53 (367) : 371 - 375
  • [38] Mechanisms of glucocorticoid resistance in human leukemic cells: Implication of abnormal 90 and 70 kDa heat shock proteins
    Kojika, S
    Sugita, K
    Inukai, T
    Saito, M
    Iijima, K
    Tezuka, T
    Goi, K
    Shiraishi, K
    Mori, T
    Okazaki, T
    Kagami, K
    Ohyama, K
    Nakazawa, S
    LEUKEMIA, 1996, 10 (06) : 994 - 999
  • [39] The cotton 70-kDa heat shock protein GhHSP70-26 plays a positive role in the drought stress response
    Ni, Zhiyong
    Liu, Na
    Yu, Yuehua
    Bi, Chenxi
    Chen, Quanjia
    Qu, Yanying
    ENVIRONMENTAL AND EXPERIMENTAL BOTANY, 2021, 191
  • [40] Small heat-shock proteins function in the insoluble protein complex
    Jiao, WW
    Li, PL
    Zhang, JR
    Zhang, H
    Chang, ZY
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 335 (01) : 227 - 231
12345