PYRIMIDINE-DERIVATIVES .6. SYNTHESIS OF MONOBROMO-SUBSTITUTED, DIBROMO-SUBSTITUTED, TRIBROMO-SUBSTITUTED, AND TETRABROMO-SUBSTITUTED PYRIMIDINE-DERIVATIVES

The following bromo-2,4(1H,3H)-pyrimidinediones possessing a bromo substituent at the 5-position and side chains at the 1- and 6-positions were prepared, The three types of mono-bromo derivatives are: 1-(bromoalkyl)-3,6-dimethyl- 3a-d, 5-bromo-3,6-dimethyl-1-(hydroxyalkyl)-4a-d, and 1-(acetoxyalkyl)-5-bromo-3,6-dimethyl-2,4(1H,3H)-pyrimidinediones 11a-d. The three types of dibromo derivatives are: 5-bromo-1-(bromoalkyl)-3,6-dimethyl- 5a-d, 1-(acetoxyalkyl)-5-bromo-6-bromomethyl- 8a, 8c, and 8d, and 5-bromo-6-bromomethyl 1-(hydroxyalkyl)-2,4(1H,3H)-pyrimidinediones 9a, 9c, and 9d. Likewise one group of tribromo and one group of tetrabromo derivatives are: 5-bromo-1-(bromoalkyl)-6-bromomethyl-7a-d and 5-bromo-1-(bromoalkyl)-6-dibromomethyl-2,4(1H,3H)-pyrimidinediones 6a-d.