T-CELL PROLIFERATIVE RESPONSE TO ANTIGENS SECRETED BY MYCOBACTERIUM-TUBERCULOSIS

被引：173
作者：
ANDERSEN, P
ASKGAARD, D
LJUNGQVIST, L
BENTZON, MW
HERON, I
机构：
[1] STATENS SERUM INST,DEPT MYCOBACTERIA,DK-2300 COPENHAGEN,DENMARK
[2] STATENS SERUM INST,DEPT BIOSTAT,DK-2300 COPENHAGEN,DENMARK
来源：
INFECTION AND IMMUNITY | 1991年 / 59卷 / 04期
关键词：
D O I：
10.1128/IAI.59.4.1558-1563.1991
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
An infection model of human tuberculosis was established with C57BL/6J mice. The lymphocyte proliferative responses to antigens from Mycobacterium tuberculosis were investigated during the course of infection and compared with results obtained with a group of mice immunized with large amounts of killed bacteria. The two groups responded similarly to a number of mycobacterial antigens, but marked differences in response against secreted antigens were found; only infected mice responded vigorously to these. The responding lymphocyte subpopulation was made up of L3T4+ T lymphocytes under restriction of the Ia molecule.
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页码：1558 / 1563
页数：6
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