ALZHEIMERS-DISEASE AMYLOID PRECURSOR PROTEIN IS PRESENT IN THE MYELIN SHEATH OF CENTRAL-NERVOUS-SYSTEM IN RAT

被引：14

作者：

IKEDA, K ^{[1
]}

TOMONAGA, M ^{[1
]}

机构：

[1] UNIV TOKYO, INST BRAIN RES, DEPT NEUROPATHOL, TOKYO 113, JAPAN

来源：

BRAIN RESEARCH | 1990年 / 527卷 / 01期

关键词：

Alzheimer's disease; Immunohistochemistry; Myelin protein; Myelination; Rat brain; β-Amyloid precursor protein;

D O I：

10.1016/0006-8993(90)91072-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By using polyclonal antibodies to C- and N-terminal portions of β-amyloid precursor protein (APP), we immunohistochemically examined postnatal and adult rat brains. Immunoreactivity was observed in myelin of nerve fibers in myelination and of mature myelinated fibers, as well as in various brain cells. In trigeminal nerve roots, the immunoreactivity was observed in central myelin but not in peripheral myelin. The results strongly suggest that APP is a component of central myelin in rat. © 1990.

引用

页码：140 / 144

页数：5

共 22 条

[1] A WHITE MATTER DISORDER IN DEMENTIA OF THE ALZHEIMER TYPE - A PATHOANATOMICAL STUDY [J].

BRUN, A ;

ENGLUND, E .

ANNALS OF NEUROLOGY, 1986, 19 (03) :253-262

[2] IMMUNOCYTOCHEMICAL LOCALIZATION OF THE PRECURSOR PROTEIN FOR BETA-AMYLOID IN THE RAT CENTRAL NERVOUS-SYSTEM [J].

CARD, JP ;

MEADE, RP ;

DAVIS, LG .

NEURON, 1988, 1 (09) :835-846

[3] QUANTITATION OF CEREBRAL ATROPHY IN PRECLINICAL AND END-STAGE ALZHEIMERS-DISEASE [J].

DELAMONTE, SM .

ANNALS OF NEUROLOGY, 1989, 25 (05) :450-459

[4] ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[5] NEURONAL LOCALIZATION OF AMYLOID BETA-PROTEIN PRECURSOR MESSENGER-RNA IN NORMAL HUMAN-BRAIN AND IN ALZHEIMERS-DISEASE [J].

GOEDERT, M .

EMBO JOURNAL, 1987, 6 (12) :3627-3632

[6] THE IMMUNOHISTOCHEMICAL DEMONSTRATION OF SUBSEQUENCES OF THE PRECURSOR OF THE AMYLOID A4-PROTEIN IN SENILE PLAQUES IN ALZHEIMERS-DISEASE [J].

ISHII, T ;

KAMETANI, F ;

HAGA, S ;

SATO, M .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1989, 15 (02) :135-147

[7] THE PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID-A4 PROTEIN RESEMBLES A CELL-SURFACE RECEPTOR [J].

KANG, J ;

LEMAIRE, HG ;

UNTERBECK, A ;

SALBAUM, JM ;

MASTERS, CL ;

GRZESCHIK, KH ;

MULTHAUP, G ;

BEYREUTHER, K ;

MULLERHILL, B .

NATURE, 1987, 325 (6106) :733-736

[8] NOVEL PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID PROTEIN SHOWS PROTEASE INHIBITORY ACTIVITY [J].

KITAGUCHI, N ;

TAKAHASHI, Y ;

TOKUSHIMA, Y ;

SHIOJIRI, S ;

ITO, H .

NATURE, 1988, 331 (6156) :530-532

[9] A NOVEL MYELIN-ASSOCIATED GLYCOPROTEIN DEFINED BY A MOUSE MONOCLONAL-ANTIBODY [J].

LINNINGTON, C ;

WEBB, M ;

WOODHAMS, PL .

JOURNAL OF NEUROIMMUNOLOGY, 1984, 6 (06) :387-396

[10]

MASTERS CL, 1987, CIBA F SYMP, V126, P49

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