Chromosomal instability, aneuploidy, and cancer

被引:24
作者
Bakhoum, Samuel F. [1 ,2 ]
Swanton, Charles [3 ,4 ]
机构
[1] Mt Auburn Hosp, Dept Internal Med, Cambridge, MA 02138 USA
[2] Harvard Med Sch, Boston, MA USA
[3] Canc Res UK London Res Inst, London, England
[4] UCL, Inst Canc, London, England
关键词
chromosomal instability; aneuploidy; anaphase; chromatin; mitosis; spindle; microtubules; centrosomes;
D O I
10.3389/fonc.2014.00161
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:3
相关论文
共 33 条
[1]   Chromosomal instability and cancer: a complex relationship with therapeutic potential [J].
Bakhoum, Samuel F. ;
Compton, Duane A. .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (04) :1138-1143
[2]   Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability [J].
Bakhoum, Samuel F. ;
Genovese, Giulio ;
Compton, Duane A. .
CURRENT BIOLOGY, 2009, 19 (22) :1937-1942
[3]   Genome stability is ensured by temporal control of kinetochore-microtubule dynamics [J].
Bakhoum, Samuel F. ;
Thompson, Sarah L. ;
Manning, Amity L. ;
Compton, Duane A. .
NATURE CELL BIOLOGY, 2009, 11 (01) :27-U51
[4]  
Boveri T., 1903, UBER MEHRPOLIGE MITO
[5]   The causes and consequences of genetic heterogeneity in cancer evolution [J].
Burrell, Rebecca A. ;
McGranahan, Nicholas ;
Bartek, Jiri ;
Swanton, Charles .
NATURE, 2013, 501 (7467) :338-345
[6]   Replication stress links structural and numerical cancer chromosomal instability [J].
Burrell, Rebecca A. ;
McClelland, Sarah E. ;
Endesfelder, David ;
Groth, Petra ;
Weller, Marie-Christine ;
Shaikh, Nadeem ;
Domingo, Enric ;
Kanu, Nnennaya ;
Dewhurst, Sally M. ;
Gronroos, Eva ;
Chew, Su Kit ;
Rowan, Andrew J. ;
Schenk, Arne ;
Sheffer, Michal ;
Howell, Michael ;
Kschischo, Maik ;
Behrens, Axel ;
Helleday, Thomas ;
Bartek, Jiri ;
Tomlinson, Ian R. ;
Swanton, Charles .
NATURE, 2013, 494 (7438) :492-496
[7]   Mutations of mitotic checkpoint genes in human cancers [J].
Cahill, DP ;
Lengauer, C ;
Yu, J ;
Riggins, GJ ;
Willson, JKV ;
Markowitz, SD ;
Kinzler, KW ;
Vogelstein, B .
NATURE, 1998, 392 (6673) :300-303
[8]   Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms [J].
Cimini, D ;
Moree, B ;
Canman, JC ;
Salmon, ED .
JOURNAL OF CELL SCIENCE, 2003, 116 (20) :4213-4225
[9]   DNA breaks and chromosome pulverization from errors in mitosis [J].
Crasta, Karen ;
Ganem, Neil J. ;
Dagher, Regina ;
Lantermann, Alexandra B. ;
Ivanova, Elena V. ;
Pan, Yunfeng ;
Nezi, Luigi ;
Protopopov, Alexei ;
Chowdhury, Dipanjan ;
Pellman, David .
NATURE, 2012, 482 (7383) :53-U70
[10]   Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy [J].
Davoli, Teresa ;
Denchi, Eros Lazzerini ;
de Lange, Titia .
CELL, 2010, 141 (01) :81-93