Integrating genomics across drug discovery and development

被引：5

作者：

Debouck, Christine ^{[1
]}

机构：

[1] Ardennes Biosci LLC, Wayne, PA 19087 USA

来源：

TOXICOLOGY LETTERS | 2009年 / 186卷 / 01期

关键词：

Genomics; Target validation; Disease mechanism; Compound optimization; Biomarkers; Pharmacogenetics; CRITICAL PATH; EXPRESSION SIGNATURES; SYSTEMS BIOLOGY; CANCER; TOXICOGENOMICS; MEDICINE; BIOMARKERS; TOXICITY; RESOURCE; GENETICS;

D O I：

10.1016/j.toxlet.2008.09.011

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The sequencing of the human genome was an exceptional achievement, but it was not an end in itself as it set the foundation for building new knowledge in biology and medicine. The laborious, multifaceted science of drug discovery and development also draws tremendous benefits from mining the human genome and exploiting the large palette of genomic technologies. This article discusses how diverse genomic tools have been used to date and how they will continue to be utilized in the future to impact drug discovery and development. Integrating genomics across drug discovery and development will undoubtedly help to shorten timelines, increase success rates at all stages and ultimately bring the right drugs to the right patients at the right times. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：9 / 12

页数：4

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