EFFECT OF CARNOSINE ON THE ACTIVITY OF LIPOXYGENASE ISOLATED FROM RABBIT RETICULOCYTES

被引：0

作者：

STVOLINSKII, SL ^{[1
]}

LANKIN, VZ ^{[1
]}

BOLDYREV, AA ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI,CARDIOL RES CTR,INST NEUROL,MOSCOW,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 01期

关键词：

15-LIPOXYGENASE; RETICULOCYTES; ARACHIDONIC ACID; CARNOSINE;

D O I：

10.1007/BF02445924

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of the histidine-containing dipeptide carnosine and of histidine on the activity of 15-lipoxygenase from rabbit reticulocytes are studied. It is shown that low concentrations of carnosine (0.5-4 mM) activate oxidation of arachidonic acid by lipoxygenase, while high concentrations (>4 mM) inhibit the enzyme activity. Histidine elicits no activatory effect, although its inhibitory activity is comparable to that of carnosine.

引用

页码：34 / 36

页数：3

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