EFFECT OF CARNOSINE ON THE ACTIVITY OF LIPOXYGENASE ISOLATED FROM RABBIT RETICULOCYTES

被引：0
|
作者：
STVOLINSKII, SL [1 ]
LANKIN, VZ [1 ]
BOLDYREV, AA [1 ]
机构：
[1] RUSSIAN ACAD MED SCI,CARDIOL RES CTR,INST NEUROL,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1995年 / 119卷 / 01期
关键词：
15-LIPOXYGENASE; RETICULOCYTES; ARACHIDONIC ACID; CARNOSINE;
D O I：
10.1007/BF02445924
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of the histidine-containing dipeptide carnosine and of histidine on the activity of 15-lipoxygenase from rabbit reticulocytes are studied. It is shown that low concentrations of carnosine (0.5-4 mM) activate oxidation of arachidonic acid by lipoxygenase, while high concentrations (>4 mM) inhibit the enzyme activity. Histidine elicits no activatory effect, although its inhibitory activity is comparable to that of carnosine.
引用
收藏
页码：34 / 36
页数：3
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