ACTIVITY OF THE SEMISYNTHETIC KANAMYCIN-B DERIVATIVE, ARBEKACIN AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS

被引：18
作者：
HAMILTONMILLER, JMT
SHAH, S
机构：
[1] Department of Medical Microbiology, Royal Free Hospital School of Medicine, London NW3 2QG, Pond St
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1995年 / 35卷 / 06期
关键词：
D O I：
10.1093/jac/35.6.865
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Arbekacin (1-N-((S)-4-amino-2-hydroxybutyryl)-3',4'-dideoxykanamycin B) was active against 54 strains of methicillin-resistant Staphylococcus nul-eus from 16 different countries, all of which were resistant to greater than or equal to 32 mg/L amikacin. MICs of arbekacin ranged from 1 to 16 mg/L, the MIC(50) was 3.2 mg/L and the mode geometric mean MICs were 4 and 4.5 mg/L respectively.
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页码：865 / 868
页数：4
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