A MONOCLONAL-ANTIBODY TO COMMON ACUTE LYMPHOBLASTIC-LEUKEMIA ANTIGEN (NEUTRAL ENDOPEPTIDASE) IMMUNOSTAINS SENILE PLAQUES IN THE BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE

被引：11

作者：

SATO, M ^{[1
]}

IKEDA, K ^{[1
]}

HAGA, S ^{[1
]}

ALLSOP, D ^{[1
]}

ISHII, T ^{[1
]}

机构：

[1] PSYCHIAT RES INST TOKYO,DEPT MOLEC BIOL,TOKYO 156,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

CALLA(CD10); MONOCLONAL ANTIBODY; NEUTRAL ENDOPEPTIDASE; SENILE PLAQUE; BETA-PROTEIN; ALZHEIMERS DISEASE;

D O I：

10.1016/0304-3940(91)90702-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We immunostained brain tissues of patients with Alzheimer's disease (AD) together with non-demented aged and younger controls with a battery of anti-human hemopoietic cell monoclonal antibodies (OK series, Ortho Diagnostics Co., Ltd. and some others) by the avidin-biotin-peroxidase complex (ABC) method to see if any epitopes are shared with the nervous system or might contribute to the neurodegenerative changes in this disease. One out of 29 monoclonal antibodies, OKBcALLa, which recognizes common acute lymphocytic leukemia antigen (CALLA, CD10), immunostained senile plaques in the brains of patients with AD. The pattern and intensity of this staining, using cryopreserved samples, was almost identical to that obtained with anti beta-protein. Thus, senile plaques in the Alzheimer's brain share an epitope with CALLA.

引用

页码：271 / 273

页数：3

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