2,9-DIMETHYL-1,10-PHENANTHROLINE (NEOCUPROINE) - A POTENT, COPPER-DEPENDENT CYTO-TOXIN WITH ANTI-TUMOR ACTIVITY

被引：52
作者：
MOHINDRU, A [1 ]
FISHER, JM [1 ]
RABINOVITZ, M [1 ]
机构：
[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,MED CHEM & PHARMACOL LAB,BLDG 37,ROOM 6D28,BETHESDA,MD 20205
来源：
BIOCHEMICAL PHARMACOLOGY | 1983年 / 32卷 / 23期
关键词：
D O I：
10.1016/0006-2952(83)90314-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：3627 / 3632
页数：6
相关论文
共 24 条
[1]  
ALBERT A, 1972, SELECTIVE TOXICITY, P334
[2]   ORTHO-PHENANTHROLINE INHIBITION OF DNA-SYNTHESIS IN MAMMALIAN-CELLS [J].
BERGER, NA ;
JOHNSON, ES ;
SKINNER, AM .
EXPERIMENTAL CELL RESEARCH, 1975, 96 (01) :145-155
[3]   BACTERICIDAL ACTION OF SELECTED PHENANTHROLINE CHELATES AND RELATED COMPOUNDS [J].
BUTLER, HM ;
HURSE, A ;
THURSKY, E ;
SHULMAN, A .
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 1969, 47 :541-&
[4]   USE OF PHENANTHROLINE METAL CHELATES FOR CONTROL TOPICAL INFECTIONS DUE TO BACTERIA, FUNGI AND PROTOZOA [J].
BUTLER, HM ;
LAVER, JC ;
SHULMAN, A ;
WRIGHT, RD .
MEDICAL JOURNAL OF AUSTRALIA, 1970, 2 (07) :309-+
[5]   TREATMENT OF DERMATOLOGICAL INFECTIONS WITH A MANGANESE PHENANTHROLINE CHELATE - A CONTROLLED CLINICAL TRIAL [J].
CADE, G ;
SHANKLY, KH ;
SHULMAN, A ;
WRIGHT, RD ;
STAHLE, IO ;
MACGIBBON, CB ;
LEWSANG, E .
MEDICAL JOURNAL OF AUSTRALIA, 1970, 2 (07) :304-+
[6]   BIOLOGICAL ACTIONS OF 1,10-PHENANTHROLINE AND 2,2'-BIPYRIDINE HYDROCHLORIDES QUATERNARY SALTS AND METAL CHELATES AND RELATED COMPOUNDS .1. BACTERIOSTATIC ACTION ON SELECTED GRAM-POSITIVE GRAM-NEGATIVE AND ACID-FAST BACTERIA [J].
DWYER, FP ;
REID, IK ;
SHULMAN, A ;
LAYCOCK, GM ;
DIXSON, S .
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 1969, 47 :203-+
[7]  
FALCHUK KH, 1977, CANCER RES, V37, P2050
[8]   ACTION OF 1,10-PHENANTHROLINE TRANSITION-METAL CHELATES AND THEIR CONSTITUENTS ON RAT ISOLATED DIAPHRAGM PREPARATION [J].
FARNWORTH, PG ;
SHULMAN, A ;
CASEY, AT .
CHEMICO-BIOLOGICAL INTERACTIONS, 1977, 18 (03) :289-294
[9]   PROTECTION AGAINST CYTO-TOXICITY OF ENDOGENOUS COPPER IN THE REQUIREMENT FOR MERCAPTOETHANOL BY A LYMPHOMA IN PRIMARY CULTURE [J].
FISHER, JM ;
RABINOVITZ, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 108 (02) :851-853
[10]   STERIC EFFECTS ON INTERCALATION OF AROMATIC CATIONS TO DEOXYRIBONUCLEIC ACID [J].
GABBAY, EJ ;
SCOFIELD, RE ;
BAXTER, CS .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (23) :7850-7857
123