A COMPARISON OF THE EFFECTS OF ANTERIOR THALAMIC, MAMILLARY BODY AND FORNIX LESIONS ON REINFORCED SPATIAL ALTERNATION

被引:137
作者
AGGLETON, JP [1 ]
NEAVE, N [1 ]
NAGLE, S [1 ]
HUNT, PR [1 ]
机构
[1] UNIV DURHAM,DEPT PSYCHOL,DURHAM DH1 3LE,ENGLAND
关键词
MAMILLARY BODY; ANTERIOR THALAMUS; FORNIX; SPATIAL MEMORY; AMNESIA; HIPPOCAMPUS; RAT;
D O I
10.1016/0166-4328(94)00163-A
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effects of cytotoxic lesions in either the anterior thalamic nuclei or the mamillary bodies were compared with those of fornix lesions on a test of spatial working memory. All three lesions impaired acquisition of a forced alternation task in a T-maze, but the disruptive effects of the mamillary body lesions were significantly less than those following either fornix or anterior thalamic damage. When the alternation task was changed, so as to increase proactive interference, the impairment associated with mamillary body damage became more evident and was now equal in severity to that in the animals with anterior thalamic lesions. The fornix lesion group were the most impaired. In contrast, all three groups performed normally on a test of object recognition. The results add weight to the view that hippocampal - anterior thalamic connections are critical for normal spatial memory and that the relative contribution of the mamillary bodies is task dependent.
引用
收藏
页码:91 / 101
页数:11
相关论文
共 29 条
[1]   BOTH FORNIX AND ANTERIOR THALAMIC, BUT NOT MAMMILLARY, LESIONS DISRUPT DELAYED NON-MATCHING-TO-POSITION MEMORY IN RATS [J].
AGGLETON, JP ;
KEITH, AB ;
SAHGAL, A .
BEHAVIOURAL BRAIN RESEARCH, 1991, 44 (02) :151-161
[2]  
AGGLETON JP, 1983, EXP BRAIN RES, V52, P199
[3]   THE CONTRIBUTION OF THE ANTERIOR THALAMIC NUCLEI TO ANTEROGRADE AMNESIA [J].
AGGLETON, JP ;
SAHGAL, A .
NEUROPSYCHOLOGIA, 1993, 31 (10) :1001-1019
[4]   REMOVAL OF THE HIPPOCAMPUS AND TRANSECTION OF THE FORNIX PRODUCE COMPARABLE DEFICITS ON DELAYED NONMATCHING TO POSITION BY RATS [J].
AGGLETON, JP ;
KEITH, AB ;
RAWLINS, JNP ;
HUNT, PR ;
SAHGAL, A .
BEHAVIOURAL BRAIN RESEARCH, 1992, 52 (01) :61-71
[5]   THE EFFECTS OF MAMMILLARY BODY AND COMBINED AMYGDALAR-FORNIX LESIONS ON TESTS OF DELAYED NON-MATCHING-TO-SAMPLE IN THE RAT [J].
AGGLETON, JP ;
HUNT, PR ;
SHAW, C .
BEHAVIOURAL BRAIN RESEARCH, 1990, 40 (02) :145-157
[6]  
AGGLETON JP, 1985, EXP BRAIN RES, V58, P190
[7]  
BENTIVOGLIO M, 1993, NEUROBIOLOGY CINGULA, P71
[8]   EFFECTS OF ANTERIOR OR DORSOMEDIAL THALAMIC IBOTENIC LESIONS ON LEARNING AND MEMORY IN RATS [J].
BERACOCHEA, DJ ;
JAFFARD, R ;
JARRARD, LE .
BEHAVIORAL AND NEURAL BIOLOGY, 1989, 51 (03) :364-376
[9]   IMPAIRMENT OF SPONTANEOUS-ALTERNATION BEHAVIOR IN SEQUENTIAL TEST PROCEDURES FOLLOWING MAMMILLARY BODY LESIONS IN MICE - EVIDENCE FOR TIME-DEPENDENT INTERFERENCE-RELATED MEMORY DEFICITS [J].
BERACOCHEA, DJ ;
JAFFARD, R .
BEHAVIORAL NEUROSCIENCE, 1987, 101 (02) :187-197
[10]   IMPAIRMENT OF MEMORY IN A DELAYED NON-MATCHING TO PLACE TASK FOLLOWING MAMILLARY BODY LESIONS IN MICE [J].
BERACOCHEA, DJ ;
ALAOUIBOUARRAQUI, F ;
JAFFARD, R .
BEHAVIOURAL BRAIN RESEARCH, 1989, 34 (1-2) :147-154