OSTEOBLASTIC METASTASIS IN ADVANCED PROSTATE-CANCER

被引：0
作者：
KOUTSILIERIS, M [1 ]
机构：
[1] UNIV LAVAL,HORMONAL BIOREGULAT LAB,QUEBEC CITY G1V 4G2,QUEBEC,CANADA
来源：
ANTICANCER RESEARCH | 1993年 / 13卷 / 02期
关键词：
OSTEOBLASTIC METASTASIS; PROSTATE CANCER; OSTEOBLAST MITOGENS;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastatic prostate cancer is unique in its ability to induce the osteoblastic reaction in skeleton. This phenomenon is probably the result of complex paracrine/autocrine cell interaction between prostate cancer cells and bone cells at the metastatic sites. Recently the use of various in vivo and in vitro systems made possible the confirmation of certain cellular interactions that may patricipate in this process. The role of IGFs/IGFBPs, urokinase-type plasminogen activator (uPA), as well as of TGF beta 1 and glucocorticoids is discussed in this review.
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页码：443 / 449
页数：7
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