SYNTHETIC GLYCOCONJUGATES .2. NORMAL-PENTENYL GLYCOSIDES AS CONVENIENT MEDIATORS FOR THE SYNTHESES OF NEW TYPES OF GLYCOPROTEIN MODELS

The efficacy of n-pentenyl glycosides as excellent carbohydrate monomers in the syntheses of pseudoglycoproteins has been systematically demonstrated. A facile procedure for the preparation of novel glycoprotein models having pendant N,N'-diacetylchitobiose [beta-D-GlcpNAc-(1-->4)-beta-D-GlcpNAc] and N-acetyllactosamine [beta-D-Galp-(1-->4)-beta-D-GlcpNAc] was established on the basis of radical copolymerization of the n-pentenylated derivatives with acrylamide. These synthetic glycoconjugates exhibited good solubility in water and had high molecular weights. The sugar contents in the macromolecules could be regulated at will as the needs of the case demand. Specific adhesion of rat hepatocytes on these matrices was also examined to show that the matrix containing N-acetyllactosamine had especially high potentials.