PHASE-II TRIAL OF PIROXANTRONE IN ADVANCED NON-SMALL-CELL CARCINOMA OF THE LUNG - A SOUTHWEST ONCOLOGY GROUP-STUDY

被引：7
|
作者：
WILLIAMSON, SK
CROWLEY, JJ
LIVINGSTON, R
HANTEL, A
DOROSHOW, JH
机构：
[1] UNIV KANSAS,MED CTR,KANSAS CITY,KS 66103
[2] PUGET SOUND CONSORTIUM,SEATTLE,WA
[3] LOYOLA UNIV,STRITCH SCH MED,MAYWOOD,IL 60153
[4] CITY HOPE NATL MED CTR,DUARTE,CA 91010
来源：
INVESTIGATIONAL NEW DRUGS | 1992年 / 10卷 / 01期
关键词：
PHASE-II; PIROXANTRONE; NON-SMALL-CELL; LUNG CANCER;
D O I：
10.1007/BF01275476
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Piroxantrone demonstrated no activity in 17 eligible patients. Toxicity was acceptable and dose escalations were performed. With only 35% (6/17) of patients experiencing grade 2 or greater granulocytopenia the study might be criticized for utilizing a less than optimal dose of piroxantrone. Based on this trial, piroxantrone is not felt to have significant antitumor activity against advanced non-small cell carcinoma of the lung. © 1992 Kluwer Academic Publishers.
引用
收藏
页码：29 / 30
页数：2
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