LOW-LEVEL LEAD-EXPOSURE DECREASES IN-VIVO RELEASE OF DOPAMINE IN THE RAT NUCLEUS-ACCUMBENS - A MICRODIALYSIS STUDY

被引：0
|
作者：
KALA, SV [1 ]
JADHAV, AL [1 ]
机构：
[1] TEXAS SO UNIV,COLL PHARM & HLTH SCI,DEPT PHARMACEUT SCI,HOUSTON,TX 77004
来源：
JOURNAL OF NEUROCHEMISTRY | 1995年 / 65卷 / 04期
关键词：
LEAD; DOPAMINE; NUCLEUS ACCUMBENS; MICRODIALYSIS; IN VIVO TOXICITY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The basal and K+-induced release of dopamine and its metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, were measured in microdialysate samples obtained in vivo from the nucleus accumbens region of rats subchronically exposed to 50 ppm lead for 90 days. The basal and stimulus-induced release of dopamine and the metabolites were significantly reduced in the lead-exposed rats as compared with the controls, These reductions in dopamine and its metabolites are consistent with the reports of decreased dopamine availability associated with lead-induced changes in certain behavioral indices (fixed-interval performance) in rats. Furthermore, these changes were observed at blood lead levels similar to those considered to cause impairment in cognitive functions in children.
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页码：1631 / 1635
页数：5
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